PREVALENCE OF PRE-ECLAMPSIA AND ECLAMPSIA AND MATERNO-FETAL OUTCOMES AT A HEALTH FACILTY IN DELTA STATE, NIGERIA
PREVALENCE AND OUTCOMES OF PRE-ECLAMPSIA AND ECLAMPSIA
DOI:
https://doi.org/10.69614/ejrh.v15i4.724Keywords:
Pre-eclampsia, Eclampsia, Prevalence, Materno-fetal outcomes, maternal complications, fetal complications.Abstract
BACKGROUND: Globally, pre-eclampsia and eclampsia complicate up to 4.6% and 1.4% of pregnancies respectively but disproportionally account for nearly 18% of all maternal death worldwide, with an estimated 62,000 to 77,000 deaths per year.
OBJECTIVE: This study determined the prevalence of pre-eclampsia and eclampsia, and compared outcomes.
METHODS: This was a retrospective cross-sectional study utilizing the case files of women admitted to the maternity ward of the obstetrics and gynaecology unit in Central Hospital, Ughelli from 1st August 2020 to 30th July 2022. Socio-demographic characteristics, maternal and fetal complications and outcomes, prevalence rate of preeclampsia and eclampsia, were presented as frequencies and percentages.
RESULTS: Of the 6291 mothers which were delivered of their babies in the maternity ward of the obstetrics and gynaecology department, 120(1.9%) were diagnosed of pre-eclampsia and eclampsia; only 108 which had complete documentation were used for the study. Age range of the participants was 16-45years, the majority, 88(81.5%) were married, had secondary education, 70(64.8%) and higher; 42(38.9%) were nulliparous at admission and 67(62%) were unbooked at the antenatal clinic. Fifty –three (49.1%) had preeclampsia while 55(50.9%) had eclampsia. Majority, 107(99.1%) were discharged home alive and 75(69.4%) had no maternal complications. Number of fetuses delivered were 114, 95 (83.3%) were born alive, 68(59.6%) weighed less than 2500g, and 91( 95.8%) neonates had a good APGAR score at the 5th minute.
CONCLUSION: The prevalence of pre-eclampsia and eclampsia was low, however there was high rates of perinatal deaths and occurrence of unfavourable materno-fetal complications.
References
2. Chen CW, Jaffe IZ, Karumanchi SA. Pre-eclampsia and Cardiovascular Disease. Cardivasc Res. 2014;101:579-86.
3. Abalos E, Cuesta C, Grosso AL, Chou D, Say L.. Global and regional estimates of preeclampsia and eclampsia: a systematic review. Eur J Obstet Gynecol Reprod Biol, 2013.;170:1–7.
4. Sibai, B. M.. Magnesium sulfate prophylaxis in preeclampsia: Lessons learned from recent trials. American Journal of Obstetrics & Gynecology, 2004; 190(6), 1520–1526. Retrieved November 14, 2018, from https://www.ncbi.nlm.nih.gov/pubmed/15284724
5. Warrington JP. Placental ischemia increases seizure susceptible and cerebrospinal fluid cytokines. Physiol Rep. 2015;3(11):e1234. [DOI]
6. Poon LC, Shennan A, Hyett JA, Kapur A, Hadar E, Divakar H, et al.,. The International Federation of Gynecology and Obstetrics (FIGO) initiative on pre-eclampsia: a pragmatic guide for first-trimester screening and prevention. Int J Gynaecol Obstet, 2019;145(Suppl 1):1–33.
7. Ghulmiyyah L, Sibai B. Maternal mortality from preeclampsia/eclampsia. Semin Perinatol, 2012;36:56–9.
8. Charan J. and Biswas T. How to Calculate Sample size for Different Designs in Medical Research? Indian Journal of Psychological Medicine, 2013;35;121-126
9. Akaba OG, Anyang IU and Ekele BA. Clinical hypertension. 2021; 27:20 BMJ Open 2019;9:e029908.
10. Onoh RC, Mamah JE, Umeokonkwo CD, Onwe EO, Ezeonu PO, Okafor L. Severe preeclampsia and eclampsia: a 6-year review at the Federal Teaching Hospital, Abakaliki, Southeast Nigeria. Trop J Obstet Gynaecol , 2019;36:418– 23.
11. Laine K, Murzakanova G, Sole KB, et al. Prevalence and risk of pre-eclampsia and gestational hypertension in twin pregnancies: a population-based register study BMJ Open 2019;9:e029908.
12. Yang Y, Le Ray I, Zhu J, Zhang J, Hua J, Reilly M. Preeclampsia Prevalence, Risk Factors, and Pregnancy Outcomes in Sweden and China. JAMA Netw Open. 2021;4(5):e218401.
13. Khan B, Allah Yar R, Khakwani AK, Karim S, Arslan Ali H. Preeclampsia Incidence and Its Maternal and Neonatal Outcomes With Associated Risk Factors. Cureus. 2022;14(11):e31143.
14. Adokiye EA, Isreal J, Tubotonye HC, Levi WO. Factors influencing the prevalence of preeclampsiaeclampsia in booked and unbooked patients: 3 years retrospective study in NDUTH, Okolobiri. World J Med Med Sci, 2015; 3: 1–14.
15. Kooffreh ME, Ekott M, Ekpoudom DO The prevalence of pre-eclampsia among pregnant women in the University of Calabar Teaching Hospital, Calabar Saudi. J Health Sci, 2014; 3:133–6.
16. Esike CO, Chukwuemeka UI, Anozie OB, Eze JN, Aluka OC, Twomey DE. Eclampsia in rural Nigeria: the unmitigating catastrophe, 2017; 16:175–80.
17. Jido TA. Ecalmpsia: maternal and fetal outcome. Afr Health Sci. 2012;12(2):148–152.
18. Vousden N, Lawley E, Seed PT, Gidiri M, Gouda SS , Sandall J, Chapell LC, Shennan AH Incidence of eclampsia and related complications across 10 low- and middle-resource geographical regions: Secondary analysis of a cluster randomised controlled trial. PLoS Med. 2019;16(3):e1002775.
19. Wassie AY and Anmut W. Prevalence of Eclampsia and Its Maternal-Fetal Outcomes at Gandhi Memorial Hospital, Addis Ababa Ethiopia, 2019: Retrospective Study. Int J Womens Health. 2021;13:231-237.
20. World Health Organization. WHO recommendations on antenatal care for a positive pregnancy experience. World Health Organization; 2016.
21. National Population Commission (Nigeria). Nigeria demographic and health survey 2018. Abuja (Nigeria): National Population Commission; 2019.
22. Tukur J, Ahonsi B, Ishaku SM, Araoyinbo I, Okereke E, Babatunde AO. Maternal and fetal outcomes after introduction of magnesium sulphate for treatment of preeclampsia and eclampsia in selected secondary facilities: a low-cost intervention. Matern Child Health J, 2013; 17:1191–8.