INVESTIGATING THE EFFECTS OF PAUSINYSTALIA YOHIMBE AQUEOUS LEAVES EXTRACT ON PARAMETERS FOR REPRODUCTIVE PERFORMANCE IN EXPERIMENTAL RATS INVESTIGATING PARAMETERS FOR REPRODUCTIVE PERFORMANCE JUSTIFYING HUMAN CIRCUMSTANCES
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Abstract
ABSTRACT
BACKGROUND: Herbal plants and herbal preparations are widely used as immunomodulatory medicines that helps in improving reproductive health in humankind, and they are globally used and have rapidly grown in economic developmental importance.
OBJECTIVE: The study was conducted to investigate the effects of the aqueous extract of P. yohimbe leaves on sexual reproductive performance in Wistar rats. The primary outcome of the study is the reproductive performance sexual rate.
METHODS: The experimental study was carried out on albino rats of the Wistar strain, weighing between 150 and 200g sexually naive. The animals were raised in polyethylene cages and divided into four groups, which received a saline solution (control group), 2, 5, and 10 mL/kg of the aqueous extract of P. yohimbe leaves for fourteen days orally. The sexual behavior test was performed according to three types of crossing.
RESULTS: The results of the treated groups showed a significant increase in mating frequency compared to the control group. Overall, the results showed that P. yohimbe significantly affects sexual behavior. The aqueous extract of P. yohimbe leaves increased sexual behaviour and orientation activity performance recorded in the treated rats.
CONCLUSION AND RECOMMENDATION: The enhanced reproductive performance appetitive detected in the study, justify the indigenous use of the herbal plant in reproductive medicine and could be a precursor in the synthesis of useful drugs. However, based on the current findings, we recommend that careful administration be considered as a better option justifying human circumstances for patient with advanced mankind age in low dosage resource settings, as it achieves a better reproductive performance rate at a lower dose dependent increase.
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Keywords: Aphrodisiac effect; herbal plant; reproductive performance parameters; experimental rat.
1. Motaleb MA, Hossain MK, Sobhan I, Alan KM, Khan NA and Firoz R. Selected Medicinal Plants of Chihagnong Mll Tracts. IUCN (International Union for Conservation of Nature), Dahaka, Bangladesh, 2011; 116.
2. Ojatula AO, Idu M and Timothy O. Aphrodisiac potentials of Pausinystalia yohimbe (K. Schum.) Pierre ex Beille aqueous root extract in male Wistar rats. Journal of Integrative Nephrology and Andrology 2020; 7(2): 47-55.
3. Ojatula AO. Spermatogenic efficacy of Pausinystalia yohimbe (K. Schum.) Piere ex Beille roots in male rats. Journal of Infertility and Reproductive Biology 2020; 8(2): 9-17.
4. Kaur C and Kapoor HC. Antioxidant activity and total phenolic content of some Asian vegetables. International Journal of Food Science and Technology 2002; 37: 153-162.
5. Wojdyło A, Jan O and Renata C. Antioxidant activity and phenolic compounds in 32 selected herbs. Food Chemistry 2007; 105: 940-949.
6. Ojatula AO. Effects of methanol extract on bioactive property and in-vitro antioxidant activity of Palma-christi (Anthocleista nobilis G. Don.) root. Pharmaceutical and Biomedical Research 2021; 7(4): 317-328.
7. Gill LS. Ethnomedicinal Uses of Plants in Nigeria. UNIBEN Press, Benin City, 1992; 275.
8. Erhabor JO, Idu M and Ojatula AO. Ethnomedicinal survey of plants used in the treatment of male sexual dysfunction among the Ilaje people of Ondo State, Nigeria. In: Kumar, S. (Ed.) Recent Advances in Ethnobotany; Deep publications: Paschim Vihar, New Delhi, India, 2015; 211.
9. Gauthaman K, Adaikan PG and Prasad RNV. Prasad aphrodisiac properties of Tribulus terrestris extract (Protodioscin) in normal and castrated rats. Life Sciences 2002; 71: 1385–1396.
10. Ojatula AO, Aworinde DO, Osewole AO and Ogungbemi AO. Aphrodisiac potential and phytochemical evaluation of aqueous extract of Microdesmis keayana J. Leonard roots. Coast Journal of Faculty of Science 2020; 1(2): 154 - 163.
11. Yakubu MT, Akanji MA and Oladiji AT. Male sexual dysfunction and methods used in assessing medicinal plants with aphrodisiac potentials. Pharmacognosy Review 2007; 1: 49-56.
12. Raskin D, Ribnicky L, Komarnytsky D, Llin S, Poulev N, Borisjuk A, et al. Plants and human health in the Twenty first century. Trends in Biotechnology 2011; 20: 522-531.
13. Watcho P, Meli W, Wankeu-Nya M, Ngadjui E, Deeh DP, Nkeng-Efouet AP. Androgenic effects of aqueous and methanolic extracts of Ficus asperifolia in male Wistar rats. BMC Complementary and Alternative Medicine 2017; 2: 17:42.
14. Zade V, Dabhadkar D, Thakare V, Pare S. Evaluation of potential aphrodisiac activity of Moringa oleifera seed in male albino rats. International Journal of Pharmacy and Pharmaceutical Sciences 2013;5(4): 683-689.
15. Preedapirom W, Changwichit K, Srisawang P, Ingkaninan K and Taepavarapruk P. (2018) Aphrodisiac activity of Eulophia mac- robulbon extract on erectile dysfunction in male aged rats. Biomedical Research International 2018; 62(2): 170 - 179.
16. Yakubu MT and Akanji MA. Effect of aqueous extract of Massularia acuminate stem on sexual behaviour of male Wistar rats. Evidence Based Complementary and Alternative Medicine 2011: 1: 73-81.
17. Dasofunjo K, Asuk AA, Ezugwu HC, Nwodo OFC and Olatunji TL. Aphrodisiac effect of ethanol extract of Piliostigma thonningii leaf on male albino wistar rats. Journal of Applied Pharmaceutical Sciences 2013; 3: 130-135.
18. Cicero AFG, Bandieri E and Arletti R. (2001) Lepidium meyenii Walp Improves sexual behaviour in male rats independently from its action on spontaneous locomotor activity. Journal of Ethnopharmacology 2001; 75: 225–229.
19. Mbongue FGY, Kamtchouing P and Essame OJL. (2005) Effect of the aqueous extract of dry fruits of Piper guineense on the reproductive function of adult male rats. Indian Journal of Pharmacology 2005; 37: 30–32.
20. Watcho P, Lih F, Deeh PBD, Wankeu-Nya M, Ngadjui E, Bonsou GRF, et al. Aphrodisiac property of aqueous and methanolic extracts of Raphia vinifera (Arecaceae) in sexually experienced male rats. International Journal of Reproductive BioMedicine 2019; 17: 413–424.