Advanced Malignant Melanoma of the Vulva in a 70 years old woman

Authors

  • BINYAM ESAYAS ABUYE a:1:{s:5:"en_US";s:22:"Addis Ababa University";}

DOI:

https://doi.org/10.69614/ejrh.v16i4.839

Abstract

Vulvar melanoma is a rare malignant tumor of the female genital tract tend to occur in older age women and a high tendency to metastasize because the diagnosis is usually delayed (1).  In this case report, we present a 70-year-old para 8 woman who presented with progressively increasing vulvar swelling of 2 years and multiple visit to health institution. Examination revealed 7cm diameter multi-nodular mass with areas of dark and dark blue-violet color filling the introitus that involves the clitoris, labia minora, lower third of the anterior vagina and urethra. Incisional biopsy from the mass showed malignant melanoma. Imaging with CT scan revealed bilateral lung metastasis. Palliative chemotherapy was planned but the patient lost to follow up. 

References

Wohlmuth C, Wohlmuth-Wieser I. Vulvar Melanoma: Molecular Characteristics, Diagnosis, Surgical Management, and Medical Treatment. Am J Clin Dermatol. 2021 Sep;22(5):639-651. doi: 10.1007/s40257-021-00614-7. Epub 2021 Jun 14. PMID: 34125416; PMCID: PMC8421300.

Khaba MC, Lekala ML, Mosehle SD. Malignant nodular melanoma of the vulva: a rare and aggressive tumour of the female genital tract (case report). Pan Afr Med J. 2021 Feb 3;38:115. doi: 10.11604/pamj.2021.38.115.25864. PMID: 33912285; PMCID: PMC8051228.

Omari M, Zaimi A, Kacem HH, Afqir S. Vulvar melanoma: A diagnostic challenge for young women - a case report. Ann Med Surg (Lond). 2022 Aug 25;81:104473. doi: 10.1016/j.amsu.2022.104473. PMID: 36147087; PMCID: PMC9486714.

Hashim M, Yayanto NH, Muda Abdullah BZ, Ramly F, Abd Rashid R, Duski DR. Vulvar malignant melanoma: A case report and review of its management. Dermatol Reports. 2022 Jul 4;14(4):9345. doi: 10.4081/dr.2022.9345. PMID: 36483218; PMCID: PMC9724639.

Dobric? EC, Vâjâitu C, Condrat CE, Cre?oiu D, Popa I, Gaspar BS, Suciu N, Cre?oiu SM, Varlas VN. Vulvar and Vaginal Melanomas-The Darker Shades of Gynecological Cancers. Biomedicines. 2021 Jun 30;9(7):758. doi: 10.3390/biomedicines9070758. PMID: 34209084; PMCID: PMC8301463.

Pedrão PG, Guimarães YM, Godoy LR, Possati-Resende JC, Bovo AC, Andrade CEMC, Longatto-Filho A, Dos Reis R. Management of Early-Stage Vulvar Cancer. Cancers (Basel). 2022 Aug 29;14(17):4184. doi: 10.3390/cancers14174184. PMID: 36077719; PMCID: PMC9454625.

Olawaiye AB, Cuello MA, Rogers LJ. Cancer of the vulva: 2021 update. Int J Gynaecol Obstet. 2021 Oct;155 Suppl 1(Suppl 1):7-18. doi: 10.1002/ijgo.13881. PMID: 34669204; PMCID: PMC9298362.

Jonathan S. Berek, Neville F. Hacker ; illustrations and design by Tim Hengst, George Barile, Deborah Berek. Berek & Hacker's Gynecologic Oncology. Philadelphia :Wolters Kluwer/Lippincott Williams & Wilkins Health, 7th edition, 2010.

Keung EZ, Gershenwald JE. The eighth edition American Joint Committee on Cancer (AJCC) melanoma staging system: implications for melanoma treatment and care. Expert Rev Anticancer Ther. 2018 Aug;18(8):775-784. doi: 10.1080/14737140.2018.1489246. PMID: 29923435; PMCID: PMC7652033.

Published

2024-11-03

How to Cite

ABUYE, B. E. (2024). Advanced Malignant Melanoma of the Vulva in a 70 years old woman . Ethiopian Journal of Reproductive Health, 16(4). https://doi.org/10.69614/ejrh.v16i4.839